29 Jan Promega Corporation Enters License Agreement with Broad Institute to Access CRISPR-Cas9 Gene Editing Technology
MADISON, Wis.–Promega Corporation announced today it has signed a non-exclusive license agreement with the Broad Institute of MIT and Harvard to sell tools and reagents for CRISPR-Cas9 gene editing, providing scientists new tools for interrogating endogenous biology. Under the agreement, Promega will combine CRISPR-Cas9 technology with its products that knock-in Promega genetic reporters to the genomes of any cell or cell line, enabling customers to explore endogenous biology at physiologically relevant expression levels.
The combination of CRISPR-Cas9 and Promega gene reporters have proven powerful in understanding critical areas of biology. A paper in the journal ACS Chemical Biology explains how the Promega HiBiT Protein Tagging System can be combined with CRISPR-Cas9-mediated gene editing to tag endogenous proteins and simplify their study under natural expression conditions. Another paper also in ACS Chemical Biology explains a strategy for monitoring PROTAC-mediated degradation of endogenously tagged HiBiT-BET family members in live cells.
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